Rotational dynamics and polarization anisotropy of bound and unbound receptor-targeted contrast agents in cancerous and normal prostate tissues studied by time-resolved fluorescence spectroscopy

Y. Pu, W. B. Wang, S. Achilefu, R. R. Alfano

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Temporal profiles of polarized fluorescence emitted from receptor-targeted contrast agents: Cybesin and Cytate, in prostate tissues were studied using ultrafast time-resolved spectroscopy. An analytical model was developed and used to investigate rotational dynamics and fluorescence polarization anisotropies of the contrast agents in prostate tissues from the measured data. The differences of rotational times and polarization anisotropies were observed for Cybesin (Cytate) in cancerous and normal prostate tissues, which reflect changes of micro-structures of cancerous and normal tissues, and their different bound affinity with contrast agents. This research may be used to develop better optical methods for in situ prostate cancer detection.

Original languageEnglish
Title of host publicationOptical Biopsy VII
DOIs
StatePublished - May 7 2010
EventOptical Biopsy VII - San Francisco, CA, United States
Duration: Jan 25 2010Jan 28 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7561
ISSN (Print)1605-7422

Conference

ConferenceOptical Biopsy VII
Country/TerritoryUnited States
CitySan Francisco, CA
Period01/25/1001/28/10

Keywords

  • Polarization anisotropy
  • Prostate cancer receptor-targeted contrast agents
  • Rotation time
  • Time-resolved fluorescence polarization kinetics

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