TY - JOUR
T1 - ROR1, an embryonic protein with an emerging role in cancer biology
AU - Borcherding, Nicholas
AU - Kusner, David
AU - Liu, Guang Hui
AU - Zhang, Weizhou
PY - 2014/7
Y1 - 2014/7
N2 - Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.
AB - Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family consisting of ROR1 and ROR2. RORs contain two distinct extracellular cysteine-rich domains and one transmembrane domain. Within the intracellular portion, ROR1 possesses a tyrosine kinase domain, two serine/threonine-rich domains and a proline-rich domain. RORs have been studied in the context of embryonic patterning and neurogenesis through a variety of homologs. These physiologic functions are dichotomous based on the requirement of the kinase domain. A growing literature has established ROR1 as a marker for cancer, such as in CLL and other blood malignancies. In addition, ROR1 is critically involved in progression of a number of blood and solid malignancies. ROR1 has been shown to inhibit apoptosis, potentiate EGFR signaling, and induce epithelial-mesenchymal transition (EMT). Importantly, ROR1 is only detectable in embryonic tissue and generally absent in adult tissue, making the protein an ideal drug target for cancer therapy.
KW - ROR1
KW - cancer
KW - embryogenesis
KW - immunotherapy
UR - http://www.scopus.com/inward/record.url?scp=84904206209&partnerID=8YFLogxK
U2 - 10.1007/s13238-014-0059-7
DO - 10.1007/s13238-014-0059-7
M3 - Article
C2 - 24752542
AN - SCOPUS:84904206209
SN - 1674-800X
VL - 5
SP - 496
EP - 502
JO - Protein and Cell
JF - Protein and Cell
IS - 7
ER -