TY - JOUR
T1 - Roles of myocardial blood volume and flow in coronary artery disease
T2 - An experimental MRI study at rest and during hyperemia
AU - McCommis, Kyle S.
AU - Goldstein, Thomas A.
AU - Abendschein, Dana R.
AU - Misselwitz, Bernd
AU - Pilgram, Thomas
AU - Gropler, Robert J.
AU - Zheng, Jie
N1 - Funding Information:
This work was supported by a grant from the National Institutes of Health R01 HL74019-01
PY - 2010/8
Y1 - 2010/8
N2 - Objective: To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand. Methods: A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and 99mTc-labeled red blood cells were injected to obtain respective gold standards. Results: Microsphere-measured MBF and 99mTc-measured MBV reference values correlated well with the M Rresults. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity. Conclusions: MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion.
AB - Objective: To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand. Methods: A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and 99mTc-labeled red blood cells were injected to obtain respective gold standards. Results: Microsphere-measured MBF and 99mTc-measured MBV reference values correlated well with the M Rresults. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity. Conclusions: MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion.
KW - Coronary stenosis
KW - Myocardial blood flow
KW - Myocardial blood volume
UR - http://www.scopus.com/inward/record.url?scp=77957962409&partnerID=8YFLogxK
U2 - 10.1007/s00330-010-1740-8
DO - 10.1007/s00330-010-1740-8
M3 - Article
C2 - 20182731
AN - SCOPUS:77957962409
SN - 0938-7994
VL - 20
SP - 2005
EP - 2012
JO - European Radiology
JF - European Radiology
IS - 8
ER -