Role of Tie1 in Shear Stress and Atherosclerosis

Kel Vin Woo; H. Scott Baldwin

doi:10.1016/j.tcm.2012.03.009

Role of Tie1 in Shear Stress and Atherosclerosis

Kel Vin Woo, H. Scott Baldwin

Research output: Contribution to journal › Review article › peer-review

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Abstract

Atherosclerotic plaques develop in a nonrandom manner along the vasculature following a hemodynamically determined distribution profile. The pathogenesis of shear stress-induced inflammation and atherosclerotic lesion formation has led to discussions about personalized strategies in prevention and treatment. Recent discoveries involving the tyrosine kinase receptor Tie1 in (1) mechanotransduction, (2) inflammation, and (3) neovascularization have invigorated these efforts. In this review, we present the current understanding on Tie1 and its role in these key components of atherogenesis.

Original language	English
Pages (from-to)	118-123
Number of pages	6
Journal	Trends in Cardiovascular Medicine
Volume	21
Issue number	4
DOIs	https://doi.org/10.1016/j.tcm.2012.03.009
State	Published - May 2011

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abstract = "Atherosclerotic plaques develop in a nonrandom manner along the vasculature following a hemodynamically determined distribution profile. The pathogenesis of shear stress-induced inflammation and atherosclerotic lesion formation has led to discussions about personalized strategies in prevention and treatment. Recent discoveries involving the tyrosine kinase receptor Tie1 in (1) mechanotransduction, (2) inflammation, and (3) neovascularization have invigorated these efforts. In this review, we present the current understanding on Tie1 and its role in these key components of atherogenesis.",

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AB - Atherosclerotic plaques develop in a nonrandom manner along the vasculature following a hemodynamically determined distribution profile. The pathogenesis of shear stress-induced inflammation and atherosclerotic lesion formation has led to discussions about personalized strategies in prevention and treatment. Recent discoveries involving the tyrosine kinase receptor Tie1 in (1) mechanotransduction, (2) inflammation, and (3) neovascularization have invigorated these efforts. In this review, we present the current understanding on Tie1 and its role in these key components of atherogenesis.

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Role of Tie1 in Shear Stress and Atherosclerosis

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