TY - JOUR
T1 - Role of thromboxane A2 in mitogenesis of vascular smooth muscle cells
AU - Dorn, G. W.
PY - 1997
Y1 - 1997
N2 - Thromboxane A2, a product of activated platelets, is a potent vasoconstrictor and promoter of vascular smooth muscle cell growth. Therefore, thromboxane has the potential to contribute to processes, such as restenosis following coronary angioplasty, characterized by both platelet activation and abnormal vascular smooth muscle growth. This article reviews the effects of thromboxane on growth of cultured vascular smooth muscle cells, discusses the mechanisms by which thromboxane transduces its growth promoting effects in tissue culture with an emphasis on the role of endogenously produced basic fibroblast growth factor, and reviews clinical studies of thromboxane synthesis inhibitors and/or receptor blockers in angioplasty restenosis.
AB - Thromboxane A2, a product of activated platelets, is a potent vasoconstrictor and promoter of vascular smooth muscle cell growth. Therefore, thromboxane has the potential to contribute to processes, such as restenosis following coronary angioplasty, characterized by both platelet activation and abnormal vascular smooth muscle growth. This article reviews the effects of thromboxane on growth of cultured vascular smooth muscle cells, discusses the mechanisms by which thromboxane transduces its growth promoting effects in tissue culture with an emphasis on the role of endogenously produced basic fibroblast growth factor, and reviews clinical studies of thromboxane synthesis inhibitors and/or receptor blockers in angioplasty restenosis.
UR - http://www.scopus.com/inward/record.url?scp=0030612854&partnerID=8YFLogxK
U2 - 10.1007/978-3-0348-7352-9_3
DO - 10.1007/978-3-0348-7352-9_3
M3 - Article
C2 - 9177099
AN - SCOPUS:0030612854
SN - 0379-0363
VL - 48
SP - 42
EP - 62
JO - Agents and Actions Supplements
JF - Agents and Actions Supplements
ER -