TY - JOUR
T1 - Role of tertiary lymphoid organs in the regulation of immune responses in the periphery
AU - Bery, Amit I.
AU - Shepherd, Hailey M.
AU - Li, Wenjun
AU - Krupnick, Alexander S.
AU - Gelman, Andrew E.
AU - Kreisel, Daniel
N1 - Funding Information:
DK is supported by National Institutes of Health grants 1P01AI116501, R01HL094601, R01HL151078, The Cystic Fibrosis Foundation, and The Foundation for Barnes-Jewish Hospital. ASK is supported by National Institutes of Health grants R01AI145108, I01BX002299 and P01AI116501. AB is supported by National Institutes of Health grant 5T32HL007317-44.
Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature Switzerland AG.
PY - 2022/7
Y1 - 2022/7
N2 - Tertiary lymphoid organs (TLOs) are collections of immune cells resembling secondary lymphoid organs (SLOs) that form in peripheral, non-lymphoid tissues in response to local chronic inflammation. While their formation mimics embryologic lymphoid organogenesis, TLOs form after birth at ectopic sites in response to local inflammation resulting in their ability to mount diverse immune responses. The structure of TLOs can vary from clusters of B and T lymphocytes to highly organized structures with B and T lymphocyte compartments, germinal centers, and lymphatic vessels (LVs) and high endothelial venules (HEVs), allowing them to generate robust immune responses at sites of tissue injury. Although our understanding of the formation and function of these structures has improved greatly over the last 30 years, their role as mediators of protective or pathologic immune responses in certain chronic inflammatory diseases remains enigmatic and may differ based on the local tissue microenvironment in which they form. In this review, we highlight the role of TLOs in the regulation of immune responses in chronic infection, chronic inflammatory and autoimmune diseases, cancer, and solid organ transplantation.
AB - Tertiary lymphoid organs (TLOs) are collections of immune cells resembling secondary lymphoid organs (SLOs) that form in peripheral, non-lymphoid tissues in response to local chronic inflammation. While their formation mimics embryologic lymphoid organogenesis, TLOs form after birth at ectopic sites in response to local inflammation resulting in their ability to mount diverse immune responses. The structure of TLOs can vary from clusters of B and T lymphocytes to highly organized structures with B and T lymphocyte compartments, germinal centers, and lymphatic vessels (LVs) and high endothelial venules (HEVs), allowing them to generate robust immune responses at sites of tissue injury. Although our understanding of the formation and function of these structures has improved greatly over the last 30 years, their role as mediators of protective or pathologic immune responses in certain chronic inflammatory diseases remains enigmatic and may differ based on the local tissue microenvironment in which they form. In this review, we highlight the role of TLOs in the regulation of immune responses in chronic infection, chronic inflammatory and autoimmune diseases, cancer, and solid organ transplantation.
KW - Autoimmune diseases
KW - Inflammation
KW - Tertiary lymphoid structures
KW - Transplantation immunology
KW - Tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85131814996&partnerID=8YFLogxK
U2 - 10.1007/s00018-022-04388-x
DO - 10.1007/s00018-022-04388-x
M3 - Review article
C2 - 35689679
AN - SCOPUS:85131814996
SN - 1420-682X
VL - 79
JO - Cellular and Molecular Life Sciences
JF - Cellular and Molecular Life Sciences
IS - 7
M1 - 359
ER -