Role of tau deposition in early cognitive decline in Down syndrome

Sigan L. Hartley; Benjamin L. Handen; Dana Tudorascu; Laise Lee; Annie Cohen; Brianna Piro-Gambetti; Matthew Zammit; William Klunk; Charles Laymon; Shahid Zaman; Beau M. Ances; Marwan Sabbagh; Bradley T. Christian

doi:10.1002/dad2.12256

Role of tau deposition in early cognitive decline in Down syndrome

Sigan L. Hartley, Benjamin L. Handen, Dana Tudorascu, Laise Lee, Annie Cohen, Brianna Piro-Gambetti, Matthew Zammit, William Klunk, Charles Laymon, Shahid Zaman, Beau M. Ances, Marwan Sabbagh, Bradley T. Christian

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14 Scopus citations

Abstract

Introduction: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [¹⁸F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). Methods: Data from 123 non-demented adults with DS (M = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [T_H] vs. low tau [T_L]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ– vs. Aβ+). Results: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ– group. The Aβ+/T_H group evidenced significantly worse episodic memory than the Aβ+/T_L group. Discussion: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.

Original language	English
Article number	e12256
Journal	Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring
Volume	14
Issue number	1
DOIs	https://doi.org/10.1002/dad2.12256
State	Published - 2022

Keywords

Alzheimer's disease
Down syndrome
amyloid
memory
positron emission tomography
tau

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10.1002/dad2.12256

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Hartley, S. L., Handen, B. L., Tudorascu, D., Lee, L., Cohen, A., Piro-Gambetti, B., Zammit, M., Klunk, W., Laymon, C., Zaman, S., Ances, B. M., Sabbagh, M., & Christian, B. T. (2022). Role of tau deposition in early cognitive decline in Down syndrome. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 14(1), Article e12256. https://doi.org/10.1002/dad2.12256

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title = "Role of tau deposition in early cognitive decline in Down syndrome",

abstract = "Introduction: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). Methods: Data from 123 non-demented adults with DS (M = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [TH] vs. low tau [TL]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ– vs. Aβ+). Results: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ– group. The Aβ+/TH group evidenced significantly worse episodic memory than the Aβ+/TL group. Discussion: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.",

keywords = "Alzheimer's disease, Down syndrome, amyloid, memory, positron emission tomography, tau",

author = "Hartley, {Sigan L.} and Handen, {Benjamin L.} and Dana Tudorascu and Laise Lee and Annie Cohen and Brianna Piro-Gambetti and Matthew Zammit and William Klunk and Charles Laymon and Shahid Zaman and Ances, {Beau M.} and Marwan Sabbagh and Christian, {Bradley T.}",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2022",

doi = "10.1002/dad2.12256",

language = "English",

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journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",

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T1 - Role of tau deposition in early cognitive decline in Down syndrome

AU - Hartley, Sigan L.

AU - Handen, Benjamin L.

AU - Tudorascu, Dana

AU - Lee, Laise

AU - Cohen, Annie

AU - Piro-Gambetti, Brianna

AU - Zammit, Matthew

AU - Klunk, William

AU - Laymon, Charles

AU - Zaman, Shahid

AU - Ances, Beau M.

AU - Sabbagh, Marwan

AU - Christian, Bradley T.

PY - 2022

Y1 - 2022

N2 - Introduction: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). Methods: Data from 123 non-demented adults with DS (M = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [TH] vs. low tau [TL]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ– vs. Aβ+). Results: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ– group. The Aβ+/TH group evidenced significantly worse episodic memory than the Aβ+/TL group. Discussion: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.

AB - Introduction: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [18F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS). Methods: Data from 123 non-demented adults with DS (M = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [TH] vs. low tau [TL]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ– vs. Aβ+). Results: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ– group. The Aβ+/TH group evidenced significantly worse episodic memory than the Aβ+/TL group. Discussion: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.

KW - Alzheimer's disease

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KW - positron emission tomography

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Role of tau deposition in early cognitive decline in Down syndrome

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