Role of sirtuins in retinal function under basal conditions

Jonathan B. Lin, Shunsuke Kubota, Raul Mostoslavsky, Rajendra S. Apte

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

Sirtuins are NAD + -dependent enzymes that govern cellular homeostasis by regulating the acylation status of their diverse target proteins. We recently demonstrated that both rod and cone photoreceptors rely on NAMPT-mediated NAD + biosynthesis to meet their energetic requirements. Moreover, we found that this NAD + -dependent retinal homeostasis relies, in part, on maintenance of optimal activity of the mitochondrial sirtuins and of SIRT3 in particular. Nonetheless, it is unknown whether other sirtuin family members also play important roles in retinal homeostasis. Our results suggest that SIRT1, SIRT2, SIRT4, and SIRT6 are dispensable for retinal survival at baseline, as individual deletion of each of these sirtuins does not cause retinal degeneration by fundus biomicroscopy or retinal dysfunction by ERG. These findings have significant implications and inform future studies investigating the mechanisms underlying the central role of NAD + biosynthesis in retinal survival and function.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
PublisherSpringer New York LLC
Pages561-567
Number of pages7
DOIs
StatePublished - 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1074
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • NAD
  • Neurodegeneration
  • Photoreceptors
  • Retina
  • Retinal degeneration
  • Sirtuins

Fingerprint

Dive into the research topics of 'Role of sirtuins in retinal function under basal conditions'. Together they form a unique fingerprint.

Cite this