Role of singlet oxygen in the degradation of hyaluronic acid

Usha P. Andley, Bireswar Chakrabarti

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


To investigate the effect of singlet oxygen on the molecular properties of hyaluronic acid, the polymer was irradiated in the presence of a dye sensitizer for singlet oxygen. Viscosity and circular dichroism techniques were used to monitor these changes. The relative viscosity of the polymer solution decreased steadily with increasing duration of irradiation, indicating an apparent decrease in molecular weight of hyaluronic acid. Circular dichroism measurements of the irradiated sample, however, did not show any appreciable change in the secondary structure, but do suggest that the generated singlet oxygen changes the tertiary structure and that this change is followed by a minor depolymerization.

Original languageEnglish
Pages (from-to)894-901
Number of pages8
JournalBiochemical and Biophysical Research Communications
Issue number3
StatePublished - Sep 30 1983


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