Role of Radiation Therapy in Cutaneous Melanoma

Jaime H. Shuff, Malika L. Siker, Mackenzie D. Daly, Christopher J. Schultz

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Cutaneous melanoma is a disease that often has an aggressive and unpredictable course. It was historically thought to be a radioresistant neoplasm; however, substantial radiobiologic and clinical evidence has emerged to refute this notion. Improved local control has been demonstrated with the use of adjuvant radiation therapy delivered to the primary site or regional lymphatics in patients with high-risk clinical or pathologic features. Despite improved local control, high-risk cutaneous melanoma often spreads systemically, leading to poor survival. In the setting of systemic progression, radiation therapy can frequently palliate symptomatic sites of metastatic disease.

Original languageEnglish
Pages (from-to)147-160
Number of pages14
JournalClinics in Plastic Surgery
Volume37
Issue number1
DOIs
StatePublished - Jan 1 2010
Externally publishedYes

Keywords

  • Adjuvant treatment
  • Cutaneous melanoma
  • Palliative radiation
  • Postoperative radiation
  • Radiation therapy

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