Since the discovery that deletion of the NF-κB subunits p50 and p52 causes osteopetrosis in mice, there has been considerable interest in the role of NF-κB signaling in bone. NF-κB controls the differentiation or activity of the major skeletal cell types- osteoclasts, osteoblasts, osteocytes and chondrocytes. However, with five NF-κB subunits and two distinct activation pathways, not all NF-κB signals lead to the same physiologic responses. In this review, we will describe the roles of various NF-κB proteins in basal bone homeostasis and disease states, and explore how NF-κB inhibition might be utilized therapeutically.

Original languageEnglish
Pages (from-to)169-182
Number of pages14
JournalCell Research
Issue number1
StatePublished - Jan 2011


  • Osteoclast
  • arthritis
  • chondrocyte
  • osteoblast
  • osteoporosis


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