TY - JOUR
T1 - Role of Midkine in Cancer Drug Resistance
T2 - Regulators of Its Expression and Its Molecular Targeting
AU - Saikia, Minakshi
AU - Cheung, Nathan
AU - Singh, Abhay Kumar
AU - Kapoor, Vaishali
N1 - Funding Information:
This study was supported by a NCI grant to V.K. (K22CA234404).
Publisher Copyright:
© 2023 by the authors.
PY - 2023/5
Y1 - 2023/5
N2 - Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers and indicates its association with multi-drug resistance in cancer. MDK, a secretory cytokine found in blood, can be exploited as a potent biomarker for the non-invasive detection of drug resistance expressed in various cancers and, thereby, can be targeted. We summarize the current information on the involvement of MDK in drug resistance, and transcriptional regulators of its expression and highlight its potential as a cancer therapeutic target.
AB - Molecules involved in drug resistance can be targeted for better therapeutic efficacies. Research on midkine (MDK) has escalated in the last few decades, which affirms a positive correlation between disease progression and MDK expression in most cancers and indicates its association with multi-drug resistance in cancer. MDK, a secretory cytokine found in blood, can be exploited as a potent biomarker for the non-invasive detection of drug resistance expressed in various cancers and, thereby, can be targeted. We summarize the current information on the involvement of MDK in drug resistance, and transcriptional regulators of its expression and highlight its potential as a cancer therapeutic target.
KW - cancer targeting
KW - drug resistance
KW - midkine
KW - transcriptional regulators
UR - http://www.scopus.com/inward/record.url?scp=85160374771&partnerID=8YFLogxK
U2 - 10.3390/ijms24108739
DO - 10.3390/ijms24108739
M3 - Review article
C2 - 37240085
AN - SCOPUS:85160374771
SN - 1661-6596
VL - 24
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 10
M1 - 8739
ER -