Role of microRNAs in plant and animal development

James C. Carrington, Victor Ambros

Research output: Contribution to journalReview articlepeer-review

1573 Scopus citations

Abstract

Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.

Original languageEnglish
Pages (from-to)336-338
Number of pages3
JournalScience
Volume301
Issue number5631
DOIs
StatePublished - Jul 18 2003

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