TY - JOUR
T1 - Role of microRNAs in plant and animal development
AU - Carrington, James C.
AU - Ambros, Victor
PY - 2003/7/18
Y1 - 2003/7/18
N2 - Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.
AB - Small RNAs, including microRNAs (miRNAs) and short interfering RNAs (siRNAs), are key components of an evolutionarily conserved system of RNA-based gene regulation in eukaryotes. They are involved in many molecular interactions, including defense against viruses and regulation of gene expression during development. miRNAs interfere with expression of messenger RNAs encoding factors that control developmental timing, stem cell maintenance, and other developmental and physiological processes in plants and animals. miRNAs are negative regulators that function as specificity determinants, or guides, within complexes that inhibit protein synthesis (animals) or promote degradation (plants) of mRNA targets.
UR - http://www.scopus.com/inward/record.url?scp=0038299558&partnerID=8YFLogxK
U2 - 10.1126/science.1085242
DO - 10.1126/science.1085242
M3 - Review article
C2 - 12869753
AN - SCOPUS:0038299558
SN - 0036-8075
VL - 301
SP - 336
EP - 338
JO - Science
JF - Science
IS - 5631
ER -