TY - JOUR
T1 - Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS)
T2 - a guideline
AU - Practice Committee of the American Society for Reproductive Medicine
AU - Penzias, Alan
AU - Bendikson, Kristin
AU - Butts, Samantha
AU - Coutifaris, Christos
AU - Falcone, Tommaso
AU - Fossum, Gregory
AU - Gitlin, Susan
AU - Gracia, Clarisa
AU - Hansen, Karl
AU - La Barbera, Andrew
AU - Mersereau, Jennifer
AU - Odem, Randall
AU - Paulson, Richard
AU - Pfeifer, Samantha
AU - Pisarska, Margareta
AU - Rebar, Robert
AU - Reindollar, Richard
AU - Rosen, Mitchell
AU - Sandlow, Jay
AU - Vernon, Michael
N1 - Publisher Copyright:
© 2017 American Society for Reproductive Medicine
PY - 2017/9
Y1 - 2017/9
N2 - Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates.
AB - Metformin alone compared with placebo increases the ovulation rate in women with polycystic ovary syndrome (PCOS) but should not be used as first-line therapy for anovulation because oral ovulation induction agents such as clomiphene citrate or letrozole alone are much more effective in increasing ovulation, pregnancy, and live-birth rates in women with PCOS. There is fair evidence that metformin alone does not increase rates of miscarriage when stopped at the initiation of pregnancy and insufficient evidence that metformin in combination with other agents used to induce ovulation increases live-birth rates.
UR - http://www.scopus.com/inward/record.url?scp=85028504796&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2017.06.026
DO - 10.1016/j.fertnstert.2017.06.026
M3 - Article
C2 - 28865539
AN - SCOPUS:85028504796
SN - 0015-0282
VL - 108
SP - 426
EP - 441
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 3
ER -