Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury

John J. Lemasters, Akira Uchiyama, Jae Sung Kim, Kazuyoshi Kon, Hartmut Jaeschke

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations
Original languageEnglish
Title of host publicationThe Liver
Subtitle of host publicationBiology and Pathobiology: Fifth Edition
PublisherJohn Wiley & Sons, Ltd
Pages511-520
Number of pages10
ISBN (Print)9780470723135
DOIs
StatePublished - Oct 6 2009
Externally publishedYes

Keywords

  • Calcein quenching in mitochondria after bafilomycin
  • Chelatable iron and cytotoxicity after oxidative stress
  • Chelatable iron storage in lysosomal/endosomal compartment and excerbating liver disease
  • Direct addition of membrane-permeable iron complexes and MPT and hepatocyte kill
  • Fluorescent probes-phen green SK and calcein
  • Intracellular iron movement role and oxidant stress in hepatocellular injury
  • Iron uptake by receptor-mediated endocytosis
  • Liver, target of injury-by ischemia reperfusion, oxidative stress, and toxic chemicals
  • Mitochondrial iron overloading and hepatic diseases
  • Mitochondrial permeability transition (MPT)

Cite this

Lemasters, J. J., Uchiyama, A., Kim, J. S., Kon, K., & Jaeschke, H. (2009). Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury. In The Liver: Biology and Pathobiology: Fifth Edition (pp. 511-520). John Wiley & Sons, Ltd. https://doi.org/10.1002/9780470747919.ch33