Role of Intracellular Iron Movement and Oxidant Stress in Hepatocellular Injury

John J. Lemasters, Akira Uchiyama, Jae Sung Kim, Kazuyoshi Kon, Hartmut Jaeschke

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

3 Scopus citations
Original languageEnglish
Title of host publicationThe Liver
Subtitle of host publicationBiology and Pathobiology: Fifth Edition
PublisherJohn Wiley & Sons, Ltd
Number of pages10
ISBN (Print)9780470723135
StatePublished - Oct 6 2009


  • Calcein quenching in mitochondria after bafilomycin
  • Chelatable iron and cytotoxicity after oxidative stress
  • Chelatable iron storage in lysosomal/endosomal compartment and excerbating liver disease
  • Direct addition of membrane-permeable iron complexes and MPT and hepatocyte kill
  • Fluorescent probes-phen green SK and calcein
  • Intracellular iron movement role and oxidant stress in hepatocellular injury
  • Iron uptake by receptor-mediated endocytosis
  • Liver, target of injury-by ischemia reperfusion, oxidative stress, and toxic chemicals
  • Mitochondrial iron overloading and hepatic diseases
  • Mitochondrial permeability transition (MPT)

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