Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue

Morichika Konishi, Hirotoshi Nakamura, Hiroyuki Miwa, Pierre Chambon, David M. Ornitz, Nobuyuki Itoh

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Fgf receptor 2c (Fgfr2c) was expressed in mature adipocytes of mouse white adipose tissue (WAT). To examine the role of Fgfr2c in mature adipocytes, we generated adipocyte-specific Fgfr2 knockout (Fgfr2 CKO) mice. The hypertrophy impairment of adipocytes in the mesenteric WAT but not in the subcutaneous WAT and decreased plasma free fatty acid (FFA) levels were observed in Fgfr2 CKO mice. Although the expression of genes involved in adipocyte differentiation and lipid metabolism in the mesenteric WAT was essentially unchanged, the expression of uncoupling protein 2 potentially involved in energy dissipation was significantly increased. Among potential Fgf ligands for Fgfr2c, Fgf9 was preferentially expressed in the mesenteric WAT. The present findings indicate that Fgfr2c potentially activated by Fgf9 plays a role in the adipocyte hypertrophy in the mesenteric WAT and FFA metabolism and/or energy dissipation in the mesenteric WAT might be involved in the hypertrophy impairment.

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalMolecular and Cellular Endocrinology
Volume287
Issue number1-2
DOIs
StatePublished - Jun 11 2008

Keywords

  • Adipocyte
  • Fgf
  • Fgf receptor
  • Hypertrophy
  • White adipose tissue

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