Role of ER stress in dysfunction of the nervous system

Kohsuke Kanekura; Simin Lu; Kathryn L. Lipson; Fumihiko Urano

doi:10.1007/978-94-007-4351-9_13

Role of ER stress in dysfunction of the nervous system

Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.

Original language	English
Title of host publication	Endoplasmic Reticulum Stress in Health and Disease
Publisher	Springer Netherlands
Pages	299-321
Number of pages	23
ISBN (Electronic)	9789400743519
ISBN (Print)	9400743505, 9789400743502
DOIs	https://doi.org/10.1007/978-94-007-4351-9_13
State	Published - Mar 1 2014

Keywords

Endoplasmic Reticulum Stress (ER stress)
Neurodegenerative disease
Neuronal cell dysfunction and death
Psychiatric illness
Unfolded Protein Response (UPR)

Access to Document

10.1007/978-94-007-4351-9_13

Cite this

@inbook{be718a3ed27540208c3427303429fbce,

title = "Role of ER stress in dysfunction of the nervous system",

abstract = "Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.",

keywords = "Endoplasmic Reticulum Stress (ER stress), Neurodegenerative disease, Neuronal cell dysfunction and death, Psychiatric illness, Unfolded Protein Response (UPR)",

author = "Kohsuke Kanekura and Simin Lu and Lipson, {Kathryn L.} and Fumihiko Urano",

year = "2014",

month = mar,

day = "1",

doi = "10.1007/978-94-007-4351-9_13",

language = "English",

isbn = "9400743505",

pages = "299--321",

booktitle = "Endoplasmic Reticulum Stress in Health and Disease",

publisher = "Springer Netherlands",

}

TY - CHAP

T1 - Role of ER stress in dysfunction of the nervous system

AU - Kanekura, Kohsuke

AU - Lu, Simin

AU - Lipson, Kathryn L.

AU - Urano, Fumihiko

PY - 2014/3/1

Y1 - 2014/3/1

N2 - Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.

AB - Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.

KW - Endoplasmic Reticulum Stress (ER stress)

KW - Neurodegenerative disease

KW - Neuronal cell dysfunction and death

KW - Psychiatric illness

KW - Unfolded Protein Response (UPR)

UR - http://www.scopus.com/inward/record.url?scp=84931466971&partnerID=8YFLogxK

U2 - 10.1007/978-94-007-4351-9_13

DO - 10.1007/978-94-007-4351-9_13

M3 - Chapter

AN - SCOPUS:84931466971

SN - 9400743505

SN - 9789400743502

SP - 299

EP - 321

BT - Endoplasmic Reticulum Stress in Health and Disease

PB - Springer Netherlands

ER -

Role of ER stress in dysfunction of the nervous system

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this