Role of ER stress in dysfunction of the nervous system

Kohsuke Kanekura, Simin Lu, Kathryn L. Lipson, Fumihiko Urano

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Recent clinical, genetic and experimental evidence indicates that dysregulation of endoplasmic reticulum (ER) homeostasis plays an important role in the pathogenesis of neurodegenerative diseases and psychiatric illness. Protein flux through the ER must be carefully monitored to prevent dysregulation of ER homeostasis and stress. ER stress elicits a signaling cascade known as the unfolded protein response (UPR) which functions in influencing both cellular life and death decisions. In this chapter, we address the transition from the physiological ER stress response to the pathological response and explore the mechanisms of ER stress-mediated dysfunction and death of neurons during the progression of neurodegenerative diseases and psychiatric illness.

Original languageEnglish
Title of host publicationEndoplasmic Reticulum Stress in Health and Disease
PublisherSpringer Netherlands
Pages299-321
Number of pages23
ISBN (Electronic)9789400743519
ISBN (Print)9400743505, 9789400743502
DOIs
StatePublished - Mar 1 2014
Externally publishedYes

Keywords

  • Endoplasmic Reticulum Stress (ER stress)
  • Neurodegenerative disease
  • Neuronal cell dysfunction and death
  • Psychiatric illness
  • Unfolded Protein Response (UPR)

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  • Cite this

    Kanekura, K., Lu, S., Lipson, K. L., & Urano, F. (2014). Role of ER stress in dysfunction of the nervous system. In Endoplasmic Reticulum Stress in Health and Disease (pp. 299-321). Springer Netherlands. https://doi.org/10.1007/978-94-007-4351-9_13