Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis

Brad W. Warner; Barbara B. Warner

doi:10.1053/j.sempedsurg.2005.05.006

Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis

Brad W. Warner, Barbara B. Warner

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.

Original language	English
Pages (from-to)	175-180
Number of pages	6
Journal	Seminars in pediatric surgery
Volume	14
Issue number	3
DOIs	https://doi.org/10.1053/j.sempedsurg.2005.05.006
State	Published - Aug 2005

Keywords

Breast milk
Enterocyte
Growth factors, Epidermal growth factor
Intestinal injury
Necrotizing enterocolitis
Saliva

Access to Document

10.1053/j.sempedsurg.2005.05.006

Cite this

@article{ad6a5a7281ff414bbd24201648c63778,

title = "Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis",

abstract = "Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.",

keywords = "Breast milk, Enterocyte, Growth factors, Epidermal growth factor, Intestinal injury, Necrotizing enterocolitis, Saliva",

author = "Warner, \{Brad W.\} and Warner, \{Barbara B.\}",

note = "Funding Information: This work is supported by National Institutes of Health RO3 DK 61596 (to B. B. Warner).",

year = "2005",

month = aug,

doi = "10.1053/j.sempedsurg.2005.05.006",

language = "English",

volume = "14",

pages = "175--180",

journal = "Seminars in pediatric surgery",

issn = "1055-8586",

number = "3",

}

TY - JOUR

T1 - Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis

AU - Warner, Brad W.

AU - Warner, Barbara B.

N1 - Funding Information: This work is supported by National Institutes of Health RO3 DK 61596 (to B. B. Warner).

PY - 2005/8

Y1 - 2005/8

N2 - Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.

AB - Neonatal necrotizing enterocolitis (NEC) is an increasingly frequent condition encountered in premature infants for which the etiology is not well understood. Epidermal growth factor (EGF) is abundant in many fluids bathing the fetal and neonatal gastrointestinal tract, including amniotic fluid, saliva, and breast milk. EGF is acknowledged to be important for normal intestinal development as well as repair following injury to the gastrointestinal mucosa. There appears to be mounting evidence to support a possible link between deficient EGF production and the development of NEC. The relevant evidence for the role of EGF in intestinal development and mucosal repair, as well as its potential involvement in the genesis of NEC will be reviewed.

KW - Breast milk

KW - Enterocyte

KW - Growth factors, Epidermal growth factor

KW - Intestinal injury

KW - Necrotizing enterocolitis

KW - Saliva

UR - https://www.scopus.com/pages/publications/23444453675

U2 - 10.1053/j.sempedsurg.2005.05.006

DO - 10.1053/j.sempedsurg.2005.05.006

M3 - Article

C2 - 16084405

AN - SCOPUS:23444453675

SN - 1055-8586

VL - 14

SP - 175

EP - 180

JO - Seminars in pediatric surgery

JF - Seminars in pediatric surgery

IS - 3

ER -

Role of epidermal growth factor in the pathogenesis of neonatal necrotizing enterocolitis

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this