TY - JOUR
T1 - Role of Dopamine Neurons in Reward and Aversion
T2 - A Synaptic Plasticity Perspective
AU - Pignatelli, Marco
AU - Bonci, Antonello
N1 - Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/6/3
Y1 - 2015/6/3
N2 - The brain is wired to predict future outcomes. Experience-dependent plasticity at excitatory synapses within dopamine neurons of the ventral tegmental area, a key region for a broad range of motivated behaviors, is thought to be a fundamental cellular mechanism that enables adaptation to a dynamic environment. Thus, depending on the circumstances, dopamine neurons are capable of processing both positive and negative reinforcement learning strategies. In this review, we will discuss how changes in synaptic plasticity of dopamine neurons may affect dopamine release, as well as behavioral adaptations to different environmental conditions falling at opposite ends of a saliency spectrum ranging from reward to aversion. Pignatelli and Bonci review emerging concepts on synaptic plasticity of dopaminergic neurons, with respect to neural processing and coding of both rewarding and aversive stimuli.
AB - The brain is wired to predict future outcomes. Experience-dependent plasticity at excitatory synapses within dopamine neurons of the ventral tegmental area, a key region for a broad range of motivated behaviors, is thought to be a fundamental cellular mechanism that enables adaptation to a dynamic environment. Thus, depending on the circumstances, dopamine neurons are capable of processing both positive and negative reinforcement learning strategies. In this review, we will discuss how changes in synaptic plasticity of dopamine neurons may affect dopamine release, as well as behavioral adaptations to different environmental conditions falling at opposite ends of a saliency spectrum ranging from reward to aversion. Pignatelli and Bonci review emerging concepts on synaptic plasticity of dopaminergic neurons, with respect to neural processing and coding of both rewarding and aversive stimuli.
UR - http://www.scopus.com/inward/record.url?scp=84930526481&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2015.04.015
DO - 10.1016/j.neuron.2015.04.015
M3 - Review article
C2 - 26050034
AN - SCOPUS:84930526481
SN - 0896-6273
VL - 86
SP - 1145
EP - 1157
JO - Neuron
JF - Neuron
IS - 5
ER -