Role of cytokines in determining T-lymphocyte function

Anne O'Garra, Kenneth Murphy

Research output: Contribution to journalArticle

376 Scopus citations

Abstract

Early events in an immune response stimulate the production of cytokines that direct the subsequent development of T-helper (Th) subsets with discrete patterns of cytokine production. These events are dictated by the type of antigen/microorganism administered to a host, as well as dose and route of immunization. Bacterial stimuli activate macrophages of the innate immune response to produce IL-12 and drive Thl development and cell-mediated immunity. Conversely, production of IL-4 early in an immune response favors a Th2 or allergic/humoral immune response. The ability of IL-4 and IL-10 to inhibit Th1 development and effector function, as well as the requirement of committed Th1 cells for co-stimulators to induce maximal IFN-γ production, suggests that cell-mediated immunity is under strict control, probably to achieve immunity with minimum immunopathology.

Original languageEnglish
Pages (from-to)458-466
Number of pages9
JournalCurrent Opinion in Immunology
Volume6
Issue number3
DOIs
StatePublished - Jun 1994

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