TY - JOUR
T1 - Rodent models clarify the role of cells expressing the substance P receptor in pain
AU - Carrasquillo, Yarimar
AU - Gereau IV, Robert W.
N1 - Funding Information:
Y.C. is supported by a National Research Service Award from the NINDS. R.G. is supported by grants from the NIMH, NINDS, and the Paralyzed Veterans of America Spinal Cord Research Foundation.
PY - 2004/11
Y1 - 2004/11
N2 - The recent failure of substance P receptor (NK1) antagonists in clinical trials for treatment of pain spawned additional studies asking why preclinical models implicating SP in chronic pain did not translate into a viable target for analgesic development. This review focuses on recent pain model system studies, suggesting that it is not SP or NK1 per se, but rather the cells that express NK1 that are crucial for maintaining chronic pain.
AB - The recent failure of substance P receptor (NK1) antagonists in clinical trials for treatment of pain spawned additional studies asking why preclinical models implicating SP in chronic pain did not translate into a viable target for analgesic development. This review focuses on recent pain model system studies, suggesting that it is not SP or NK1 per se, but rather the cells that express NK1 that are crucial for maintaining chronic pain.
UR - http://www.scopus.com/inward/record.url?scp=23744507907&partnerID=8YFLogxK
U2 - 10.1016/j.ddmod.2004.09.009
DO - 10.1016/j.ddmod.2004.09.009
M3 - Review article
AN - SCOPUS:23744507907
SN - 1740-6757
VL - 1
SP - 107
EP - 113
JO - Drug Discovery Today: Disease Models
JF - Drug Discovery Today: Disease Models
IS - 2
ER -