Rodent models clarify the role of cells expressing the substance P receptor in pain

Yarimar Carrasquillo, Robert W. Gereau IV

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

The recent failure of substance P receptor (NK1) antagonists in clinical trials for treatment of pain spawned additional studies asking why preclinical models implicating SP in chronic pain did not translate into a viable target for analgesic development. This review focuses on recent pain model system studies, suggesting that it is not SP or NK1 per se, but rather the cells that express NK1 that are crucial for maintaining chronic pain.

Original languageEnglish
Pages (from-to)107-113
Number of pages7
JournalDrug Discovery Today: Disease Models
Volume1
Issue number2
DOIs
StatePublished - Nov 2004

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