TY - JOUR
T1 - Rod and cone visual pigments and phototransduction through pharmacological, genetic, and physiological approaches
AU - Kefalov, Vladimir J.
PY - 2012/1/13
Y1 - 2012/1/13
N2 - Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.
AB - Activation of the visual pigment by light in rod and cone photoreceptors initiates our visual perception. As a result, the signaling properties of visual pigments, consisting of a protein, opsin, and a chromophore, 11-cis-retinal, play a key role in shaping the light responses of photoreceptors. The combination of pharmacological, physiological, and genetic tools has been a powerful approach advancing our understanding of the interactions between opsin and chromophore and how they affect the function of visual pigments. The signaling properties of the visual pigments modulate many aspects of the function of rods and cones, producing their unique physiological properties.
UR - http://www.scopus.com/inward/record.url?scp=84855837416&partnerID=8YFLogxK
U2 - 10.1074/jbc.R111.303008
DO - 10.1074/jbc.R111.303008
M3 - Short survey
C2 - 22074928
AN - SCOPUS:84855837416
SN - 0021-9258
VL - 287
SP - 1635
EP - 1641
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 3
ER -