RNA-Seq identifies genes whose proteins are transformative in the differentiation of cytotrophoblast to syncytiotrophoblast, in human primary villous and BeWo trophoblasts

Christopher Azar, Mark Valentine, Julie Trausch-Azar, Todd Druley, D. Michael Nelson, Alan L. Schwartz

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The fusion of villous cytotrophoblasts into the multinucleated syncytiotrophoblast is critical for the essential functions of the mammalian placenta. Using RNA-Seq gene expression and quantitative protein expression, we identified genes and their cognate proteins which are coordinately up- or down-regulated in two cellular models of cytotrophoblast to syncytiotrophoblast development, human primary villous and human BeWo cytotrophoblasts. These include hCGβ, TREML2, PAM, CRIP2, INHA, FLRG, SERPINF1, C17orf96, KRT17 and SAA1. These findings provide avenues for further understanding the mechanisms underlying mammalian placental synctiotrophoblast development.

Original languageEnglish
Article number5142
JournalScientific reports
Volume8
Issue number1
DOIs
StatePublished - Dec 1 2018

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