RNA ligase does the AMP shuffle

John M. Pascal, Tom Ellenberger

Research output: Contribution to journalShort surveypeer-review

2 Scopus citations


Crystal structures of T4 RNA ligase 2 trapped at different stages of a multistep reaction show how one enzyme active site juggles three phosphoryl transfer reactions to join two RNA strands. The structures also show how the ligase enzyme selectively recognizes the sugar pucker of ribose to achieve catalytic specificity toward RNA-containing substrates.

Original languageEnglish
Pages (from-to)950-951
Number of pages2
JournalNature Structural and Molecular Biology
Issue number11
StatePublished - Nov 2006


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