RNA and Proteins: Mutual Respect

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Abstract

Proteins and RNA are often found in ribonucleoprotein particles (RNPs), where they function in cellular processes to synthesize proteins (the ribosome), chemically modify RNAs (small nucleolar RNPs), splice pre-mRNAs (the spliceosome), and, on a larger scale, sequester RNAs, degrade them, or process them (P bodies, Cajal bodies, and nucleoli). Each RNA-protein interaction is a story in itself, as both molecules can change conformation, compete for binding sites, and regulate cellular functions. Recent studies of Xist long non-coding RNP, the U4/5/6 tri-small nuclear RNP complex, and an activated state of a spliceosome reveal new features of RNA interactions with proteins, and, although their stories are incomplete, they are already fascinating.

Original languageEnglish
Article number345
JournalF1000Research
Volume6
DOIs
StatePublished - 2017

Keywords

  • LncRNA
  • RNA-protein interaction
  • RNPs
  • Ribonucleoprotein Particles
  • U4/5/6 tri-snRNP complex
  • Xist

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