Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

Ofer Zimmerman; Berenice Rösler; Christa S. Zerbe; Lindsey B. Rosen; Amy P. Hsu; Gulbu Uzel; Alexandra F. Freeman; Elizabeth P. Sampaio; Sergio D. Rosenzweig; Hye Sun Kuehn; Tiffany Kim; Kristina M. Brooks; Parag Kumar; Xiaowen Wang; Mihai G. Netea; Frank L. Van De Veerdonk; Steven M. Holland

doi:10.1093/ofid/ofx202

Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

Ofer Zimmerman
, Berenice Rösler
, Christa S. Zerbe
, Lindsey B. Rosen
, Amy P. Hsu
, Gulbu Uzel
, Alexandra F. Freeman
, Elizabeth P. Sampaio
, Sergio D. Rosenzweig
, Hye Sun Kuehn
, Tiffany Kim
, Kristina M. Brooks
, Parag Kumar
, Xiaowen Wang
, Mihai G. Netea
, Frank L. Van De Veerdonk
, Steven M. Holland

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

Original language	English
Article number	ofx202
Journal	Open Forum Infectious Diseases
Volume	4
Issue number	4
DOIs	https://doi.org/10.1093/ofid/ofx202
State	Published - 2017

Keywords

STAT1
coccidiomycosis
dermatophytosis
gain of function
ruxolitinib

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10.1093/ofid/ofx202

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Zimmerman, O., Rösler, B., Zerbe, C. S., Rosen, L. B., Hsu, A. P., Uzel, G., Freeman, A. F., Sampaio, E. P., Rosenzweig, S. D., Kuehn, H. S., Kim, T., Brooks, K. M., Kumar, P., Wang, X., Netea, M. G., Van De Veerdonk, F. L., & Holland, S. M. (2017). Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease. Open Forum Infectious Diseases, 4(4), Article ofx202. https://doi.org/10.1093/ofid/ofx202

@article{a128ed94671f495fbafea2619510cafa,

title = "Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease",

abstract = "Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.",

keywords = "STAT1, coccidiomycosis, dermatophytosis, gain of function, ruxolitinib",

author = "Ofer Zimmerman and Berenice R{\"o}sler and Zerbe, \{Christa S.\} and Rosen, \{Lindsey B.\} and Hsu, \{Amy P.\} and Gulbu Uzel and Freeman, \{Alexandra F.\} and Sampaio, \{Elizabeth P.\} and Rosenzweig, \{Sergio D.\} and Kuehn, \{Hye Sun\} and Tiffany Kim and Brooks, \{Kristina M.\} and Parag Kumar and Xiaowen Wang and Netea, \{Mihai G.\} and \{Van De Veerdonk\}, \{Frank L.\} and Holland, \{Steven M.\}",

year = "2017",

doi = "10.1093/ofid/ofx202",

language = "English",

volume = "4",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

number = "4",

}

Zimmerman, O, Rösler, B, Zerbe, CS, Rosen, LB, Hsu, AP, Uzel, G, Freeman, AF, Sampaio, EP, Rosenzweig, SD, Kuehn, HS, Kim, T, Brooks, KM, Kumar, P, Wang, X, Netea, MG, Van De Veerdonk, FL & Holland, SM 2017, 'Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease', Open Forum Infectious Diseases, vol. 4, no. 4, ofx202. https://doi.org/10.1093/ofid/ofx202

TY - JOUR

T1 - Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

AU - Zimmerman, Ofer

AU - Rösler, Berenice

AU - Zerbe, Christa S.

AU - Rosen, Lindsey B.

AU - Hsu, Amy P.

AU - Uzel, Gulbu

AU - Freeman, Alexandra F.

AU - Sampaio, Elizabeth P.

AU - Rosenzweig, Sergio D.

AU - Kuehn, Hye Sun

AU - Kim, Tiffany

AU - Brooks, Kristina M.

AU - Kumar, Parag

AU - Wang, Xiaowen

AU - Netea, Mihai G.

AU - Van De Veerdonk, Frank L.

AU - Holland, Steven M.

PY - 2017

Y1 - 2017

N2 - Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

AB - Heterozygous STAT1 gain-of-function (GOF) mutations are associated with chronic mucocutaneous candidiasis and a broad spectrum of infectious, inflammatory, and vascular manifestations. We describe therapeutic failures with the Janus Kinase (JAK) inhibitor ruxolitinib in 2 STAT1 GOF patients with severe invasive or cutaneous fungal infections.

KW - STAT1

KW - coccidiomycosis

KW - dermatophytosis

KW - gain of function

KW - ruxolitinib

UR - https://www.scopus.com/pages/publications/85048934575

U2 - 10.1093/ofid/ofx202

DO - 10.1093/ofid/ofx202

M3 - Article

AN - SCOPUS:85048934575

SN - 2328-8957

VL - 4

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 4

M1 - ofx202

ER -

Risks of Ruxolitinib in STAT1 Gain-of-Function-Associated Severe Fungal Disease

Abstract

Keywords

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