Risk Stratification and Survival after Myocardial Infarction

Roger Lester, Arthur J. Moss, J. Thomas Bigger, Robert B. Case, John A. Gillespie, Robert E. Goldstein, Henry M. Greenberg, Ronald Krone, Frank I. Marcus, Charles L. Odoroff, G. Charles Oliver, Frank I. Marcus, Leonard Cobb, Jesse Edwards, Lewis Kuller, Charles L. Odoroff, Henry T. Davis, Joseph L. Fleiss, J. Phillip Miller

Research output: Contribution to journalArticlepeer-review

1511 Scopus citations


We assessed the role of physiologic measurements of heart function in predicting mortality after myocardial infarction. Most of the 866 patients enrolled in our multicenter study underwent 24-hour Holter monitoring and determination of the resting radionuclide ventricular ejection fraction before discharge. Univariate analyses showed a progressive increase in cardiac mortality during one year as the ejection fraction fell below 0.40 and as the number of ventricular ectopic depolarizations exceeded one per hour. Only four risk factors among eight prespecified variables were independent predictors of mortality: an ejection fraction below 0.40, ventricular ectopy of 10 or more depolarizations per hour, advanced New York Heart Association functional class before infarction, and rales heard in the upper two thirds of the lung fields while the patient was in the coronary-care unit. Various combinations of these four factors identified five risk subgroups with two-year mortality rates ranging from 3 per cent (no factors) to 60 per cent (all four factors). (N Engl J Med 1983; 309:331–6.).

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalNew England Journal of Medicine
Issue number6
StatePublished - Aug 11 1983


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