TY - JOUR
T1 - Risk of Multiple Sclerosis Exacerbation During Pregnancy and Breast-feeding
AU - the Multiple Sclerosis Study Group
AU - Nelson, Lorene M.
AU - Franklin, Gary M.
AU - Jones, Monica C.
AU - Belendiuk, George
AU - Kasper, Barbara
AU - Klatzman, Diane
AU - Mietlowski, William
AU - Solch, Suzanne
AU - Franklin, Gary
AU - Burks, Jack
AU - Nelson, Lorene
AU - Wangaard, Carolyn
AU - Mcfarland, Henry
AU - Goodman, Andrew
AU - Dale,
AU - Krebs, Helen
AU - Maloni, Heidi
AU - Debronozo, Joe
AU - Labe,
AU - Traugott, Ute
AU - Aisen, Mindy
AU - Robbins, Kate
AU - Sibley, William
AU - Laguna, Jose
AU - Laguna, Joan
AU - John,
AU - Cliford, David
AU - Smith, Larry
AU - Mclnnis, Jane
AU - Arnason, Barry
AU - Roos, Raymond
AU - Reder, Anthony
AU - Antel, Jack
AU - Aguis, Mark
AU - Martia, Roberta
AU - Hurwitz, Barrie
AU - Greenburg, Steven
AU - Fredane, Louis
AU - Herbstreith, Rebecca
AU - Hurwitz, Jean
AU - Johnson, Kenneth
AU - Panitch, Hillel
AU - Koski, Carol Lee
AU - Fishman, Paul
AU - Haley, Sue
AU - Petajan, Jack
AU - Bray, Patrick
AU - Rose, John
AU - Thurman, David
AU - Galster, William
AU - Tourtellotte, Wallace
AU - Baumhefner, R. W.
AU - Ellison, George
AU - Myers, Lawrence
AU - Syndulko, Karl
AU - Newton, Lavona
AU - Wolinsky, Jerry
AU - Sears, E. Simon
AU - Nath, Avindra
AU - Weisbrodt, Catherine
PY - 1988/6/17
Y1 - 1988/6/17
N2 - Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.
AB - Studies in the past have reported an increased risk of exacerbations in multiple sclerosis during the postpartum period; it is not known whether breast-feeding alters this risk. We interviewed 435 women regarding pregnancy and breast-feeding history, providing for analysis 191 pregnancies that had occurred during a nonprogressive phase of the disease. The exacerbation rates during the nine-month postpartum period (34%) were more than three times the exacerbation rate during the nine months of pregnancy (10%). The exacerbation risk was highest in the three-month period following childbirth and appeared to stabilize after the sixth postpartum month. The exacerbation rates in breast-feeding and non—breast-feeding pregnancies were 38% and 31%, respectively. The average time to exacerbation was similar in breast-feeding (3.0 months) and non—breast-feeding (3.1 months) pregnancies. Although differential exacerbation rates during pregnancy and the postpartum period may be related to hormonal effects on the immune system, the hormonal effects of breast-feeding do not appear to similarly affect the risk of exacerbation.
UR - http://www.scopus.com/inward/record.url?scp=0023688129&partnerID=8YFLogxK
U2 - 10.1001/jama.1988.03720230051029
DO - 10.1001/jama.1988.03720230051029
M3 - Article
C2 - 3373681
AN - SCOPUS:0023688129
SN - 0098-7484
VL - 259
SP - 3441
EP - 3443
JO - JAMA: The Journal of the American Medical Association
JF - JAMA: The Journal of the American Medical Association
IS - 23
ER -