Risk of Harm Associated With Using Rapid Sequence Induction Intubation and Positive Pressure Ventilation in Patients With Hemorrhagic Shock

Patrick Thompson, Anthony J. Hudson, Victor A. Convertino, Christopher Bjerkvig, Hakon S. Eliassen, Brian J. Eastridge, Timm Irvine-Smith, Maxwell A. Braverman, Stefan Hellander, Donald H. Jenkins, Joseph F. Rappold, Jennifer M. Gurney, Elon Glassberg, Andrew P. Cap, Sylviain Aussett, Torunn O. Apelseth, Steve Williams, Kevin R. Ward, Stacy A. Shackelford, Pierre StrobergBjarne H. Vikeness, Paul E. Pepe, Christopher J. Winckler, Tom Woolley, Stefan Enbuske, Marc De Pasquale, Ken D. Boffard, Ivar Austlid, Theodore K. Fosse, Helge Asbjornsen, Philip C. Spinella, Geir Strandenes

Research output: Contribution to journalEditorial

3 Scopus citations


Based on limited published evidence, physiological principles, clinical experience, and expertise, the author group has developed a consensus statement on the potential for iatrogenic harm with rapid sequence induction (RSI) intubation and positive-pressure ventilation (PPV) on patients in hemorrhagic shock. "In hemorrhagic shock, or any low flow (central hypovolemic) state, it should be noted that RSI and PPV are likely to cause iatrogenic harm by decreasing cardiac output." The use of RSI and PPV leads to an increased burden of shock due to a decreased cardiac output (CO)2 which is one of the primary determinants of oxygen delivery (DO2). The diminishing DO2 creates a state of systemic hypoxia, the severity of which will determine the magnitude of the shock (shock dose) and a growing deficit of oxygen, referred to as oxygen debt. Rapid accumulation of critical levels of oxygen debt results in coagulopathy and organ dysfunction and failure. Spontaneous respiration induced negative intrathoracic pressure (ITP) provides the pressure differential driving venous return. PPV subsequently increases ITP and thus right atrial pressure. The loss in pressure differential directly decreases CO and DO2 with a resultant increase in systemic hypoxia. If RSI and PPV are deemed necessary, prior or parallel resuscitation with blood products is required to mitigate post intervention reduction of DO2 and the potential for inducing cardiac arrest in the critically shocked patient.

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of special operations medicine : a peer reviewed journal for SOF medical professionals
Issue number3
StatePublished - Sep 1 2020


Dive into the research topics of 'Risk of Harm Associated With Using Rapid Sequence Induction Intubation and Positive Pressure Ventilation in Patients With Hemorrhagic Shock'. Together they form a unique fingerprint.

Cite this