Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer

Samuel Swisher-Mcclure, Nandita Mitra, Alexander Lin, Peter Ahn, Fei Wan, Bert O'Malley, Gregory S. Weinstein, Justin E. Bekelman

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Background This study compared the risk of fatal cerebrovascular accidents (CVAs) in patients with early-stage glottic laryngeal cancer receiving surgery or external beam radiation therapy (EBRT). Methods Using a competing risks survival analysis, we compared the risk of death because of CVA among patients with early-stage glottic laryngeal cancer receiving surgery or EBRT in the Surveillance, Epidemiology, and End Results (SEER) database. Results The cumulative incidence of fatal CVA at 15 years was higher in patients receiving EBRT (2.8%; 95% confidence interval [CI], 2.3% to 3.4%) compared to surgery (1.5%; 95% CI, 0.8% to 2.3%; p = .024). In multivariable competing risks regression models, EBRT remained associated with an increased risk of fatal CVA compared to surgery (adjusted hazard ratio [HR], 1.75; 95% CI, 1.04-2.96; p = .037). Conclusion Treatment for early-stage glottic laryngeal cancer with EBRT was associated with a small increase in the risk of late fatal CVA events relative to surgery.

Original languageEnglish
Pages (from-to)611-616
Number of pages6
JournalHead and Neck
Volume36
Issue number5
DOIs
StatePublished - May 2014
Externally publishedYes

Keywords

  • cerebrovascular accidents
  • laryngeal cancer
  • radiation therapy

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    Swisher-Mcclure, S., Mitra, N., Lin, A., Ahn, P., Wan, F., O'Malley, B., Weinstein, G. S., & Bekelman, J. E. (2014). Risk of fatal cerebrovascular accidents after external beam radiation therapy for early-stage glottic laryngeal cancer. Head and Neck, 36(5), 611-616. https://doi.org/10.1002/hed.23342