It is increasingly being recognized that breast cancer does not represent a single homogeneous disease; instead, the hormone-receptor status defines important clinical and etiologic differences. We review the epidemiologic data on differences in risk-factor associations by hormone-receptor status and highlight major trends in the literature. We discuss the development and evaluation of breast cancer risk models, with a focus on the Rosner and Colditz model, which can separately estimate the risk of hormone-receptor-positive and hormone-receptor-negative breast cancers. We also discuss the clinical implications of accounting for hormone-receptor status in breast cancer risk-prediction models.

Original languageEnglish
Pages (from-to)415-423
Number of pages9
JournalNature Clinical Practice Oncology
Issue number7
StatePublished - Jul 2007


Dive into the research topics of 'Risk factors and hormone-receptor status: Epidemiology, risk-prediction models and treatment implications for breast cancer'. Together they form a unique fingerprint.

Cite this