72 Scopus citations

Abstract

It is increasingly being recognized that breast cancer does not represent a single homogeneous disease; instead, the hormone-receptor status defines important clinical and etiologic differences. We review the epidemiologic data on differences in risk-factor associations by hormone-receptor status and highlight major trends in the literature. We discuss the development and evaluation of breast cancer risk models, with a focus on the Rosner and Colditz model, which can separately estimate the risk of hormone-receptor-positive and hormone-receptor-negative breast cancers. We also discuss the clinical implications of accounting for hormone-receptor status in breast cancer risk-prediction models.

Original languageEnglish
Pages (from-to)415-423
Number of pages9
JournalNature Clinical Practice Oncology
Volume4
Issue number7
DOIs
StatePublished - Jul 2007

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