Members of the class B1 family of G-protein coupled receptors (GPCRs) whose ligands are neuropeptides have been implicated in regulation of circadian rhythms and sleep in diverse metazoan clades. This review discusses the cellular and molecular mechanisms by which class B1 GPCRs, especially the mammalian VPAC2 receptor and its functional homologue PDFR in Drosophila and C. elegans, regulate arousal and daily rhythms of sleep and wake. There are remarkable parallels in the cellular and molecular roles played by class B1 intercellular signaling pathways in coordinating arousal and circadian timekeeping across multiple cells and tissues in these very different genetic model organisms.

Original languageEnglish
Pages (from-to)18-30
Number of pages13
JournalCritical Reviews in Biochemistry and Molecular Biology
Issue number1
StatePublished - Jan 1 2015


  • Circadian
  • Drosophila
  • G-protein coupled receptor
  • Neuropeptides
  • Sleep
  • Suprachiasmatic nucleus


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