Rheumatic manifestations of parvovirus B19 in children

Melinda R. Reed, Brooke E. Gilliam, Reema H. Syed, Terry L. Moore

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


It is well known that parvovirus B19 causes erythema infectiosum, a common febrile exanthema of childhood. Studies have also shown that parvovirus B19 can cause chronic arthropathy in children, and some children may meet classification criteria for juvenile idiopathic arthritis. A child's anti-B19 antibodies may cross-react with other antigens leading to autoantibody formation and immune complex deposition. This process can cause a similar clinical picture to systemic lupus erythematosus, and in some cases has been implicated in initiation of disease. Parvovirus B19 has also been linked to the presence of antiphospholipid antibodies, juvenile dermatomyositis, vasculitides, immune thrombocytopenic purpura, and hemophagocytic lymphohistiocytosis. This review provides an extensive evaluation of the literature on parvovirus B19 and its role in rheumatic diseases in children.

Original languageEnglish
Pages (from-to)333-342
Number of pages10
JournalJournal of Pediatric Infectious Diseases
Issue number4
StatePublished - Nov 11 2009


  • Hemophagocytic lymphohistiocytosis
  • Immune thrombocytopenic purpura
  • Juvenile dermatomyositis
  • Juvenile idiopathic arthritis
  • Parvovirus B19
  • Pediatrics
  • Rheumatology
  • Systemic lupus erythematosus
  • Vasculitis


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