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Vesicular stomatitis virus (VSV) has long served as paradigm for understanding the strategies of viral genome replication of the non-segmented negative-strand (NNS) RNA viruses or order Mononegavirales. Although the primary focus of this chapter will be to summarize our current knowledge based upon work performed with VSV-Indiana or VSIV it should be emphasized that there are important distinctions between different Rhabdoviridae family members, notably some of the plant viruses exhibit a nuclear phase to their replication cycle. In addition, while the general principles from studying the cis-acting signals and trans-acting factors derived from study of VSIV hold true for other viruses, the nucleotide (nt) sequence of the signals themselves are distinct and the protein-protein interactions may be accomplished by distinct residues.

Original languageEnglish
Title of host publicationViral Genome Replication
PublisherSpringer US
Number of pages18
ISBN (Electronic)9780387894560
ISBN (Print)9780387894256
StatePublished - Jan 1 2009
Externally publishedYes

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    Whelan, S. P. J. (2009). Rhabdoviruses. In Viral Genome Replication (pp. 145-162). Springer US. https://doi.org/10.1007/b135974_8