Rh immune globulin after genetic amniocentesis: Impact on pregnancy outcome

J. P. Crane, B. Rohland, D. Larson

    Research output: Contribution to journalArticlepeer-review

    2 Scopus citations


    Although Rh immune globulin is commonly given to Rh-negative women undergoing genetic amniocentesis, there is little documentation of the necessity, efficacy, or safety of this policy. In this study, reproductive outcomes in 147 women each receiving 150 μg of Rh immune globulin after genetic amniocentesis were compared with those of an equal number of Rh-positive amniocentesis control women. No significant differences were found in the incidence of midtrimester pregnancy loss, mean gestational age at delivery, mean birth weight, or frequency of preterm deliveries (P>0.05 for all parameters). While two antepartum stillbirths occurred in the study group and none in the control population, causes unrelated to Rh immune globulin administration were apparent for both fetal deaths (one mutiple congenital anomaly syndrome, one abruptio placentae at 38 weeks). Of 103 Rh-negative women giving birth to Rh-positive infants, none were overtly sensitized at the time of delivery. It is concluded that second trimester Rh immune globulin adminstiration does not increase the risk of pregnancy loss.

    Original languageEnglish
    Pages (from-to)763-768
    Number of pages6
    JournalAmerican journal of medical genetics
    Issue number4
    StatePublished - 1984


    Dive into the research topics of 'Rh immune globulin after genetic amniocentesis: Impact on pregnancy outcome'. Together they form a unique fingerprint.

    Cite this