Review Pathogenesis of Cholesterol Gallstones

Steven M. Strasberg, Pierre Alain Clavien, P. Robert, C. Harvey

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Cholesterol gallstone disease is extremely common. Three major stages are recognized for stone formation, namely bile that becomes supersaturated with cholesterol, cholesterol nucleation leading to crystal formation and finally retention of the crystals in the gallbladder resulting in stone formation. Supersaturation is common but nucleation into crystals probably requires protein nucleating factors. Impaired motility of the gallbladder causes crystal retention and is probably very important in stone formation.

Original languageEnglish
Pages (from-to)79-102
Number of pages24
JournalHPB Surgery
Issue number2
StatePublished - 1991


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