TY - JOUR
T1 - Reversible Photothermal Modulation of Electrical Activity of Excitable Cells using Polydopamine Nanoparticles
AU - Gholami Derami, Hamed
AU - Gupta, Prashant
AU - Weng, Kuo Chan
AU - Seth, Anushree
AU - Gupta, Rohit
AU - Silva, Jonathan R.
AU - Raman, Baranidharan
AU - Singamaneni, Srikanth
N1 - Funding Information:
The authors acknowledge support from Air Force Office of Scientific Research (#FA95501910394 (S.S. and B.R.)) and National Institutes of Health (R01-HL136553 (J.R.S.)). The authors thank Nano Research Facility (NRF) and Institute of Materials Science and Engineering at Washington University for providing access to electron microscopy facilities.
Funding Information:
The authors acknowledge support from Air Force Office of Scientific Research (#FA95501910394 (S.S. and B.R.)) and National Institutes of Health (R01‐HL136553 (J.R.S.)). The authors thank Nano Research Facility (NRF) and Institute of Materials Science and Engineering at Washington University for providing access to electron microscopy facilities.
Publisher Copyright:
© 2021 Wiley-VCH GmbH.
PY - 2021/8/12
Y1 - 2021/8/12
N2 - Advances in the design and synthesis of nanomaterials with desired biophysicochemical properties can be harnessed to develop non-invasive neuromodulation technologies. Here, the reversible modulation of the electrical activity of neurons and cardiomyocytes is demonstrated using polydopamine (PDA) nanoparticles as photothermal nanotransducers. In addition to their broad light absorption and excellent photothermal activity, PDA nanoparticles are highly biocompatible and biodegradable, making them excellent candidates for both in vitro and in vivo applications. The modulation of the activity (i.e., spike rate of the neurons and beating rate of cardiomyocytes) of excitable cells can be finely controlled by varying the excitation power density and irradiation duration. Under optimal conditions, reversible suppression (≈100%) of neural activity and reversible enhancement (two-fold) in the beating rate of cardiomyocytes is demonstrated. To improve the ease of interfacing of photothermal transducers with these excitable cells and enable spatial localization of the photothermal stimulus, a collagen/PDA nanoparticle foam is realized, which can be used as an “add-on patch” for photothermal stimulation. The non-genetic optical neuromodulation approach using biocompatible and biodegradable nanoparticles represents a minimally invasive method for controlling the activity of excitable cells with potential applications in nano-neuroscience and engineering.
AB - Advances in the design and synthesis of nanomaterials with desired biophysicochemical properties can be harnessed to develop non-invasive neuromodulation technologies. Here, the reversible modulation of the electrical activity of neurons and cardiomyocytes is demonstrated using polydopamine (PDA) nanoparticles as photothermal nanotransducers. In addition to their broad light absorption and excellent photothermal activity, PDA nanoparticles are highly biocompatible and biodegradable, making them excellent candidates for both in vitro and in vivo applications. The modulation of the activity (i.e., spike rate of the neurons and beating rate of cardiomyocytes) of excitable cells can be finely controlled by varying the excitation power density and irradiation duration. Under optimal conditions, reversible suppression (≈100%) of neural activity and reversible enhancement (two-fold) in the beating rate of cardiomyocytes is demonstrated. To improve the ease of interfacing of photothermal transducers with these excitable cells and enable spatial localization of the photothermal stimulus, a collagen/PDA nanoparticle foam is realized, which can be used as an “add-on patch” for photothermal stimulation. The non-genetic optical neuromodulation approach using biocompatible and biodegradable nanoparticles represents a minimally invasive method for controlling the activity of excitable cells with potential applications in nano-neuroscience and engineering.
KW - light-to-heat conversion
KW - nano–neuro interfaces
KW - neuromodulation
KW - photothermal stimulation
KW - polydopamine nanoparticles
UR - http://www.scopus.com/inward/record.url?scp=85109022835&partnerID=8YFLogxK
U2 - 10.1002/adma.202008809
DO - 10.1002/adma.202008809
M3 - Article
C2 - 34216406
AN - SCOPUS:85109022835
SN - 0935-9648
VL - 33
JO - Advanced Materials
JF - Advanced Materials
IS - 32
M1 - 2008809
ER -