Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting

Giuseppe Mazzoni, Pietro Mazzoni

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The aim of this research was to investigate whether cyclosporin‐A (Cy‐A) could exert its action on graft rejection in progress. For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). In one group of animals, Cy‐A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy‐A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.

Original languageEnglish
Pages (from-to)114-116
Number of pages3
JournalMicrosurgery
Volume7
Issue number3
DOIs
StatePublished - 1986
Externally publishedYes

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