Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting

Giuseppe Mazzoni; Pietro Mazzoni

doi:10.1002/micr.1920070303

Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting

Giuseppe Mazzoni, Pietro Mazzoni

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Abstract

The aim of this research was to investigate whether cyclosporin‐A (Cy‐A) could exert its action on graft rejection in progress. For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). In one group of animals, Cy‐A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy‐A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.

Original language	English
Pages (from-to)	114-116
Number of pages	3
Journal	Microsurgery
Volume	7
Issue number	3
DOIs	https://doi.org/10.1002/micr.1920070303
State	Published - 1986

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title = "Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting",

abstract = "The aim of this research was to investigate whether cyclosporin‐A (Cy‐A) could exert its action on graft rejection in progress. For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). In one group of animals, Cy‐A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy‐A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.",

author = "Giuseppe Mazzoni and Pietro Mazzoni",

year = "1986",

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AU - Mazzoni, Giuseppe

AU - Mazzoni, Pietro

PY - 1986

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AB - The aim of this research was to investigate whether cyclosporin‐A (Cy‐A) could exert its action on graft rejection in progress. For this purpose, heartlung grafting was performed in a strong hystoincompatible combination of rats (BN/LEW). In one group of animals, Cy‐A was administered at the dose of 15 mg/kg daily for 10 days starting on the 5th day after grafting. In a control group only olive oil was administered. Five of six animals treated with Cy‐A showed a graft survival over 4 weeks and in two cases it was over 2 months when they were killed.

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JO - Microsurgery

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ER -

Reversibility of graft rejection following a short cyclosporin‐a administration 5 days after grafting

Abstract

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