TY - JOUR
T1 - Reverse remodeling in Dilated Cardiomyopathy
T2 - Insights and future perspectives
AU - Merlo, M.
AU - Caiffa, T.
AU - Gobbo, M.
AU - Adamo, L.
AU - Sinagra, G.
N1 - Publisher Copyright:
© 2017
PY - 2018/3
Y1 - 2018/3
N2 - Dilated Cardiomyopathy (DCM) has been classically considered a progressive disease of the heart muscle that inexorably progresses towards refractory heart failure, ventricular arrhythmias and heart transplant. However, the prognosis of DCM has significantly improved in the past few years, mostly as the result of successful therapy-induced reverse remodeling. Reverse remodeling is a complex process that involves not only the left ventricle, but also many other cardiac structures and it is now recognized both as a measure of therapeutic effectiveness and as an important prognostic tool. Nevertheless, several aspects of reverse remodeling remain unclear, including the best timing for its quantification, its predictors and its interaction with individual genetic backgrounds. In this review, we summarize our current understanding of reverse remodeling in patients with DCM and provide practical recommendations for the clinical management of this challenging patient population.
AB - Dilated Cardiomyopathy (DCM) has been classically considered a progressive disease of the heart muscle that inexorably progresses towards refractory heart failure, ventricular arrhythmias and heart transplant. However, the prognosis of DCM has significantly improved in the past few years, mostly as the result of successful therapy-induced reverse remodeling. Reverse remodeling is a complex process that involves not only the left ventricle, but also many other cardiac structures and it is now recognized both as a measure of therapeutic effectiveness and as an important prognostic tool. Nevertheless, several aspects of reverse remodeling remain unclear, including the best timing for its quantification, its predictors and its interaction with individual genetic backgrounds. In this review, we summarize our current understanding of reverse remodeling in patients with DCM and provide practical recommendations for the clinical management of this challenging patient population.
UR - http://www.scopus.com/inward/record.url?scp=85043335134&partnerID=8YFLogxK
U2 - 10.1016/j.ijcha.2018.02.005
DO - 10.1016/j.ijcha.2018.02.005
M3 - Review article
C2 - 29876504
AN - SCOPUS:85043335134
SN - 2352-9067
VL - 18
SP - 52
EP - 57
JO - IJC Heart and Vasculature
JF - IJC Heart and Vasculature
ER -