@article{60957188c26b4c0bb65294bf6b3fd039,
title = "Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway",
abstract = "At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.",
author = "Puglielli, \{Maryann T.\} and Browning, \{Jeffrey L.\} and Brewer, \{Avery W.\} and Schreiber, \{Robert D.\} and Shieh, \{Wun Ju\} and Altman, \{John D.\} and Oldstone, \{M. B.A.\} and Zaki, \{Sherif R.\} and Rafi Ahmed",
note = "Funding Information: This work was funded in part by NIH grants AI09866, AI30048 and NS21496. All animals used in experiments described here were treated in accordance with Emory University{\textquoteright}s guidelines.",
year = "1999",
month = dec,
doi = "10.1038/70938",
language = "English",
volume = "5",
pages = "1370--1374",
journal = "Nature medicine",
issn = "1078-8956",
number = "12",
}