Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

Maryann T. Puglielli; Jeffrey L. Browning; Avery W. Brewer; Robert D. Schreiber; Wun Ju Shieh; John D. Altman; M. B.A. Oldstone; Sherif R. Zaki; Rafi Ahmed

doi:10.1038/70938

Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

Maryann T. Puglielli
, Jeffrey L. Browning
, Avery W. Brewer
, Robert D. Schreiber
, Wun Ju Shieh
, John D. Altman
, M. B.A. Oldstone
, Sherif R. Zaki
, Rafi Ahmed

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

Original language	English
Pages (from-to)	1370-1374
Number of pages	5
Journal	Nature medicine
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/70938
State	Published - Dec 1999

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10.1038/70938

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@article{60957188c26b4c0bb65294bf6b3fd039,

title = "Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway",

abstract = "At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.",

author = "Puglielli, \{Maryann T.\} and Browning, \{Jeffrey L.\} and Brewer, \{Avery W.\} and Schreiber, \{Robert D.\} and Shieh, \{Wun Ju\} and Altman, \{John D.\} and Oldstone, \{M. B.A.\} and Zaki, \{Sherif R.\} and Rafi Ahmed",

note = "Funding Information: This work was funded in part by NIH grants AI09866, AI30048 and NS21496. All animals used in experiments described here were treated in accordance with Emory University{\textquoteright}s guidelines.",

year = "1999",

month = dec,

doi = "10.1038/70938",

language = "English",

volume = "5",

pages = "1370--1374",

journal = "Nature medicine",

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T1 - Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

AU - Puglielli, Maryann T.

AU - Browning, Jeffrey L.

AU - Brewer, Avery W.

AU - Schreiber, Robert D.

AU - Shieh, Wun Ju

AU - Altman, John D.

AU - Oldstone, M. B.A.

AU - Zaki, Sherif R.

AU - Ahmed, Rafi

N1 - Funding Information: This work was funded in part by NIH grants AI09866, AI30048 and NS21496. All animals used in experiments described here were treated in accordance with Emory University’s guidelines.

PY - 1999/12

Y1 - 1999/12

N2 - At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

AB - At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

UR - https://www.scopus.com/pages/publications/0032752092

U2 - 10.1038/70938

DO - 10.1038/70938

M3 - Article

C2 - 10581078

AN - SCOPUS:0032752092

SN - 1078-8956

VL - 5

SP - 1370

EP - 1374

JO - Nature medicine

JF - Nature medicine

IS - 12

ER -

Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

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