Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway

Maryann T. Puglielli, Jeffrey L. Browning, Avery W. Brewer, Robert D. Schreiber, Wun Ju Shieh, John D. Altman, M. B.A. Oldstone, Sherif R. Zaki, Rafi Ahmed

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

At present, little is known about the pathogenesis of acute virus- induced shock and pulmonary failure. A chief impediment in understanding the underlying disease mechanisms and developing treatment strategies has been the lack of a suitable animal model. This study describes a mouse model of virus-induced systemic shock and respiratory distress, and shows that blockade of the lymphotoxin beta receptor pathway reverses the disease.

Original languageEnglish
Pages (from-to)1370-1374
Number of pages5
JournalNature medicine
Volume5
Issue number12
DOIs
StatePublished - Dec 1 1999

Fingerprint Dive into the research topics of 'Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway'. Together they form a unique fingerprint.

  • Cite this

    Puglielli, M. T., Browning, J. L., Brewer, A. W., Schreiber, R. D., Shieh, W. J., Altman, J. D., Oldstone, M. B. A., Zaki, S. R., & Ahmed, R. (1999). Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway. Nature medicine, 5(12), 1370-1374. https://doi.org/10.1038/70938