TY - JOUR
T1 - Reversal of neuropathic and gastrointestinal complications related to diabetes mellitus in adolescents with improved metabolic control
AU - White, Neil H.
AU - Waltman, Stephen R.
AU - Krupin, Theodore
AU - Santiago, Julio V.
N1 - Funding Information:
From the Division of Metabolism and Endocrinology, St. Louis Children's Hospital, and the Edward Mallinckrodt Department of Pediatrics and the Departments of Ophthalmology and Medicine, Washington University School of Medicine. Supported in part by grants from the Diabetic Children's' Welfare Association, American Diabetes Association (St. Louis Affiliate), and National Institutes of Health grants AM20579, RRO0036, EY02198, and EYO0082 (Dr. Krupin). *Reprint address': P.O. Box 14871, St. Louis, MO 63178.
PY - 1981/7
Y1 - 1981/7
N2 - Two adolescents with insulin-dependent diabetes mellitus developed unusually severe diabetic neuropathy which responded to intensive measures to achieve improved metabolic control. Employing home blood glucose monitoring and either frequent insulin injections or a portable insulin infusion pump, painful peripheral neuropathy and autonomic gastrointestinal neuropathy improved after five and 12 months of therapy, respectively. During this period of time, abnormal ocular fluorophotometry, an early change in the eye of diabetic patients, also returned to normal. These patients demonstrate the reversibility of unusually severe neuropathy and early ocular changes in adolescents with diabetes when treated with intensive measures designed to improve metabolic control.
AB - Two adolescents with insulin-dependent diabetes mellitus developed unusually severe diabetic neuropathy which responded to intensive measures to achieve improved metabolic control. Employing home blood glucose monitoring and either frequent insulin injections or a portable insulin infusion pump, painful peripheral neuropathy and autonomic gastrointestinal neuropathy improved after five and 12 months of therapy, respectively. During this period of time, abnormal ocular fluorophotometry, an early change in the eye of diabetic patients, also returned to normal. These patients demonstrate the reversibility of unusually severe neuropathy and early ocular changes in adolescents with diabetes when treated with intensive measures designed to improve metabolic control.
UR - http://www.scopus.com/inward/record.url?scp=0019433610&partnerID=8YFLogxK
U2 - 10.1016/S0022-3476(81)80954-7
DO - 10.1016/S0022-3476(81)80954-7
M3 - Article
C2 - 7019402
AN - SCOPUS:0019433610
SN - 0022-3476
VL - 99
SP - 41
EP - 45
JO - The Journal of Pediatrics
JF - The Journal of Pediatrics
IS - 1
ER -