Revealing rate-limiting steps in complex disease biology: The crucial importance of studying rare, extreme-phenotype families

Keyphrases

• Complex Disease 100%
• Rate-limiting Step 100%
• Gene Regulatory Network 100%
• Extreme Phenotypes 100%
• Disease Biology 100%
• Transcription Factor 33%
• Complex Phenotypes 33%
• Genetic Disease 33%
• Specific Genes 33%
• Mutant Phenotype 33%
• Complex Traits 33%
• Genomic Analysis 33%
• Complex Disorders 33%
• Abnormal Phenotype 33%
• Sequence Variants 33%
• Cis-regulatory Elements 33%
• Functional Alterations 33%
• Mutual Feedback Relationship 33%

Biochemistry, Genetics and Molecular Biology

• Gene Regulatory Network 100%
• Genetic Disorder 33%
• Transcription Factors 33%
• Transcription 33%
• Cis-Regulatory Element 33%