TY - JOUR
T1 - Retinotopic organization of human visual cortex mapped with positron-emission tomography
AU - Fox, Peter T.
AU - Miezin, Francis M.
AU - Allman, John M.
AU - Van Essen, David C.
AU - Raichlei, Marcus E.
PY - 1987
Y1 - 1987
N2 - The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated-state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum-detection algorithm to subtraction-format images of the stimulus-induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower-field) caused systematic, highly significant changes in response locale witin visual cortex. Discrete extrastriate visual responses were also observed.
AB - The retinotopic organization of primary visual cortex was mapped in normal human volunteers. Positron-emission tomographic measurements of regional cerebral blood flow were employed to detect focal functional brain activation. Oxygen-15-labeled water, delivered by intravenous bolus, was used as the blood flow tracer to allow multiple stimulated-state (n = 5) and control-state (n = 3) measurements to be acquired for each of 7 subjects. Responses were identified by applying a maximum-detection algorithm to subtraction-format images of the stimulus-induced change in cerebral blood flow. Response locales were described using a standardized system of stereotactic coordinates. Changes in stimulus location (macular, perimacular, peripheral, upper-field, lower-field) caused systematic, highly significant changes in response locale witin visual cortex. Discrete extrastriate visual responses were also observed.
UR - http://www.scopus.com/inward/record.url?scp=0023147612&partnerID=8YFLogxK
U2 - 10.1523/jneurosci.07-03-00913.1987
DO - 10.1523/jneurosci.07-03-00913.1987
M3 - Article
C2 - 3494107
AN - SCOPUS:0023147612
SN - 0270-6474
VL - 7
SP - 913
EP - 922
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 3
ER -