Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalBiochemical Journal
Issue number1
StatePublished - 1991


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