Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

D. H. Davis; U. R. Rapp; N. O. Davidson

doi:10.1042/bj2780043

Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

D. H. Davis, U. R. Rapp, N. O. Davidson

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57 Scopus citations

Abstract

Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [³H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.

Original language	English
Pages (from-to)	43-47
Number of pages	5
Journal	Biochemical Journal
Volume	278
Issue number	1
DOIs	https://doi.org/10.1042/bj2780043
State	Published - 1991

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title = "Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation",

abstract = "Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.",

author = "Davis, {D. H.} and Rapp, {U. R.} and Davidson, {N. O.}",

year = "1991",

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AU - Davis, D. H.

AU - Rapp, U. R.

AU - Davidson, N. O.

PY - 1991

Y1 - 1991

N2 - Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.

AB - Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.

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JO - Biochemical Journal

JF - Biochemical Journal

IS - 1

ER -

Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

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