Retinoic acid and transforming growth factor β differentially inhibit platelet-derived-growth-factor-induced Ito-cell activation

D. H. Davis, U. R. Rapp, N. O. Davidson

Research output: Contribution to journalArticlepeer-review

54 Scopus citations

Abstract

Sinusoidal Ito cells (stellate or fat-storing cells) undergo excessive cellular proliferation before the establishment and progression of hepatic fibrosis and cirrhosis. Retinoic acid and transforming growth factor β (TGFβ) both inhibit Ito-cell [3H]thymidine incorporation in serum-containing media. Serum-induced mitogenicity was dependent on platelet-derived growth factor (PDGF). Additionally, pre-treatment of Ito cells with retinoic acid and TGFβ blocked PDGF-induced cell proliferation. TGFβ, but not retinoic acid, diminished PDGF-receptor and smooth-muscle α-actin abundance.

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalBiochemical Journal
Volume278
Issue number1
DOIs
StatePublished - 1991

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