Abstract
Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.
| Original language | English |
|---|---|
| Pages (from-to) | 104-106 |
| Number of pages | 3 |
| Journal | Seminars in Diagnostic Pathology |
| Volume | 11 |
| Issue number | 2 |
| State | Published - Jan 1 1994 |
Keywords
- RB1
- Retinoblastoma
- embryology
- osteogenic sarcoma
- pinealoma
- second tumor
- tumorigenesis
Fingerprint
Dive into the research topics of 'Retinoblastoma'. Together they form a unique fingerprint.Cite this
- APA
- Author
- BIBTEX
- Harvard
- Standard
- RIS
- Vancouver