TY - JOUR
T1 - Retinoblastoma metastatic to the ovary in a patient with Waardenburg syndrome
AU - Moshfeghi, Darius M.
AU - Wilson, Matthew W.
AU - Haik, Barrett G.
AU - Hill, D. Ashley
AU - Rodriguez-Galindo, Carlos
AU - Pratt, Charles B.
N1 - Funding Information:
Supported in part by unrestricted grants from Research to Prevent Blindness, New York, and from the St. Giles Foundation, New York; by Cancer Support (CORE) Grant P30-CA21765 and Grant P30-CA23099 from the National Cancer Institute, Bethesda, Maryland; and by the American Lebanese Syrian Associated Charities (ALSAC), Memphis, Tennessee.
PY - 2002
Y1 - 2002
N2 - PURPOSE: To report a child with retinoblastoma and Waardenburg syndrome who developed ovarian metastases. DESIGN: Interventional case report. METHODS: Unilateral retinoblastoma was diagnosed in a 3-year-old girl with Waardenburg syndrome and leukocoria in the right eye. The patient had a Reese-Ellsworth Group Va tumor and underwent enucleation. Two years later, she developed metastatic disease involving the bone marrow, right humerus, both supraorbital bones, and both tibias. She was treated with chemotherapy, orbital irradiation, and bone marrow transplant but returned 7 months later with back pain and urinary retention. RESULTS: Exploratory laparotomy revealed a right ovarian mass, and the excised ovary showed metastatic retinoblastoma. The child underwent chemotherapy and remained asymptomatic for 9 months, when brain metastases were diagnosed. She died within 2 days of admission. CONCLUSION: We believe that this is the first description of a patient with retinoblastoma and Waardenburg syndrome and of an ovarian metastasis from retinoblastoma.
AB - PURPOSE: To report a child with retinoblastoma and Waardenburg syndrome who developed ovarian metastases. DESIGN: Interventional case report. METHODS: Unilateral retinoblastoma was diagnosed in a 3-year-old girl with Waardenburg syndrome and leukocoria in the right eye. The patient had a Reese-Ellsworth Group Va tumor and underwent enucleation. Two years later, she developed metastatic disease involving the bone marrow, right humerus, both supraorbital bones, and both tibias. She was treated with chemotherapy, orbital irradiation, and bone marrow transplant but returned 7 months later with back pain and urinary retention. RESULTS: Exploratory laparotomy revealed a right ovarian mass, and the excised ovary showed metastatic retinoblastoma. The child underwent chemotherapy and remained asymptomatic for 9 months, when brain metastases were diagnosed. She died within 2 days of admission. CONCLUSION: We believe that this is the first description of a patient with retinoblastoma and Waardenburg syndrome and of an ovarian metastasis from retinoblastoma.
UR - http://www.scopus.com/inward/record.url?scp=0036253159&partnerID=8YFLogxK
U2 - 10.1016/S0002-9394(02)01352-1
DO - 10.1016/S0002-9394(02)01352-1
M3 - Article
C2 - 11992879
AN - SCOPUS:0036253159
SN - 0002-9394
VL - 133
SP - 716
EP - 718
JO - American journal of ophthalmology
JF - American journal of ophthalmology
IS - 5
ER -