G. T. Lueder, M. E. Smith

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.

Original languageEnglish
Pages (from-to)104-106
Number of pages3
JournalSeminars in Diagnostic Pathology
Issue number2
StatePublished - Jan 1 1994


  • RB1
  • Retinoblastoma
  • embryology
  • osteogenic sarcoma
  • pinealoma
  • second tumor
  • tumorigenesis


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