Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.
|Number of pages||3|
|Journal||Seminars in Diagnostic Pathology|
|State||Published - Jan 1 1994|
- osteogenic sarcoma
- second tumor