Retinoblastoma

G. T. Lueder; M. E. Smith

Retinoblastoma

G. T. Lueder, M. E. Smith

Department of Ophthalmology and Visual Sciences

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.

Original language	English
Pages (from-to)	104-106
Number of pages	3
Journal	Seminars in Diagnostic Pathology
Volume	11
Issue number	2
State	Published - Jan 1 1994

Keywords

RB1
Retinoblastoma
embryology
osteogenic sarcoma
pinealoma
second tumor
tumorigenesis

Cite this

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title = "Retinoblastoma",

abstract = "Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.",

keywords = "RB1, Retinoblastoma, embryology, osteogenic sarcoma, pinealoma, second tumor, tumorigenesis",

author = "Lueder, {G. T.} and Smith, {M. E.}",

year = "1994",

month = jan,

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language = "English",

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pages = "104--106",

journal = "Seminars in Diagnostic Pathology",

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AU - Lueder, G. T.

AU - Smith, M. E.

PY - 1994/1/1

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N2 - Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.

AB - Retinoblastoma (RB) is the most common intraocular malignancy of childhood, occurring in approximately 1 in 20,000 live births. It arises from pluripotential retinal progenitor cells. Mutations of the RB1 gene interfere with regulation of the cell cycle. Patients who harbor a germinal mutation of the RB1 gene are at risk for the development of second, non-ocular tumors.

KW - RB1

KW - Retinoblastoma

KW - embryology

KW - osteogenic sarcoma

KW - pinealoma

KW - second tumor

KW - tumorigenesis

UR - http://www.scopus.com/inward/record.url?scp=0027932265&partnerID=8YFLogxK

M3 - Article

C2 - 7809503

AN - SCOPUS:0027932265

SN - 0740-2570

VL - 11

SP - 104

EP - 106

JO - Seminars in Diagnostic Pathology

JF - Seminars in Diagnostic Pathology

IS - 2

ER -

Retinoblastoma

Abstract

Keywords

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