TY - JOUR
T1 - Restriction fragment length polymorphisms associated with the gene for the major intrinsic protein of eye-lens fibre cell membranes in mice with hereditary cataracts
AU - Shiels, Alan
AU - Griffin, Carol S.
AU - Muggleton-Harris, Audrey L.
PY - 1991/7/26
Y1 - 1991/7/26
N2 - Cloned cDNAs coding for eye-lens fibre cell-membrane proteins, MIP and MP70, were used to detect restriction fragment length polymorphisms (RFLPs) in genomic DNA from inbred mice with autosomally inherited cataracts. Whereas distinct RFLPs associated with the MIP gene were identified in the Cba Cat and Nct mutants, no such genetic variation was associated with the MP70 gene. RFLPs associated with the mouse MIP gene may provide informative DNA markers in gene linkage studies of murine hereditary cataracts.
AB - Cloned cDNAs coding for eye-lens fibre cell-membrane proteins, MIP and MP70, were used to detect restriction fragment length polymorphisms (RFLPs) in genomic DNA from inbred mice with autosomally inherited cataracts. Whereas distinct RFLPs associated with the MIP gene were identified in the Cba Cat and Nct mutants, no such genetic variation was associated with the MP70 gene. RFLPs associated with the mouse MIP gene may provide informative DNA markers in gene linkage studies of murine hereditary cataracts.
KW - (Mouse)
KW - Hereditary cataract RFLP
KW - Lens
KW - MIP
KW - MP70
UR - http://www.scopus.com/inward/record.url?scp=0025823078&partnerID=8YFLogxK
U2 - 10.1016/0925-4439(91)90028-8
DO - 10.1016/0925-4439(91)90028-8
M3 - Article
C2 - 1677593
AN - SCOPUS:0025823078
SN - 0925-4439
VL - 1097
SP - 81
EP - 85
JO - BBA - Molecular Basis of Disease
JF - BBA - Molecular Basis of Disease
IS - 1
ER -