Restriction endonucleases: One of these things is not like the others

Eric A. Galburt; Barry L. Stoddard

doi:10.1038/72450

Restriction endonucleases: One of these things is not like the others

Eric A. Galburt, Barry L. Stoddard

Research output: Contribution to journal › Short survey › peer-review

9 Scopus citations

Abstract

The crystal structure of the restriction endonuclease Bg/II in complex with its DNA target site has been determined. The DNA binding mode and chemistry of catalysis are observed to differ from BamHI which cleaves a similar target site. These observations indicate that more divergence has occurred within this family of proteins than originally thought.

Original language	English
Pages (from-to)	89-91
Number of pages	3
Journal	Nature Structural Biology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1038/72450
State	Published - Feb 2000

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title = "Restriction endonucleases: One of these things is not like the others",

abstract = "The crystal structure of the restriction endonuclease Bg/II in complex with its DNA target site has been determined. The DNA binding mode and chemistry of catalysis are observed to differ from BamHI which cleaves a similar target site. These observations indicate that more divergence has occurred within this family of proteins than originally thought.",

author = "Galburt, {Eric A.} and Stoddard, {Barry L.}",

note = "Funding Information: E.A.G. is supported by an NIH training grant fellowship; B.L.S. is funded for studies in this field by the NIH. The authors thank C. Lukacs and A. Aggarwal for providing coordinates prior to publication and release and for comments on this summary.",

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AU - Galburt, Eric A.

AU - Stoddard, Barry L.

N1 - Funding Information: E.A.G. is supported by an NIH training grant fellowship; B.L.S. is funded for studies in this field by the NIH. The authors thank C. Lukacs and A. Aggarwal for providing coordinates prior to publication and release and for comments on this summary.

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N2 - The crystal structure of the restriction endonuclease Bg/II in complex with its DNA target site has been determined. The DNA binding mode and chemistry of catalysis are observed to differ from BamHI which cleaves a similar target site. These observations indicate that more divergence has occurred within this family of proteins than originally thought.

AB - The crystal structure of the restriction endonuclease Bg/II in complex with its DNA target site has been determined. The DNA binding mode and chemistry of catalysis are observed to differ from BamHI which cleaves a similar target site. These observations indicate that more divergence has occurred within this family of proteins than originally thought.

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JO - Nature Structural Biology

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Restriction endonucleases: One of these things is not like the others

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